Journal Article

Flexible structural protein alignment by a sequence of local transformations

Jairo Rocha, Joan Segura, Richard C. Wilson and Swagata Dasgupta

in Bioinformatics

Volume 25, issue 13, pages 1625-1631
Published in print July 2009 | ISSN: 1367-4803
Published online May 2009 | e-ISSN: 1460-2059 | DOI:

More Like This

Show all results sharing this subject:

  • Bioinformatics and Computational Biology


Show Summary Details


Motivation: Throughout evolution, homologous proteins have common regions that stay semi-rigid relative to each other and other parts that vary in a more noticeable way. In order to compare the increasing number of structures in the PDB, flexible geometrical alignments are needed, that are reliable and easy to use.

Results: We present a protein structure alignment method whose main feature is the ability to consider different rigid transformations at different sites, allowing for deformations beyond a global rigid transformation. The performance of the method is comparable with that of the best ones from 10 aligners tested, regarding both the quality of the alignments with respect to hand curated ones, and the classification ability. An analysis of some structure pairs from the literature that need to be matched in a flexible fashion are shown. The use of a series of local transformations can be exported to other classifiers, and a future golden protein similarity measure could benefit from it.

Availability: A public server for the program is available at


Supplementary information: All data used, results and examples are available at data are available at Bioinformatics online.

Journal Article.  5715 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.