Journal Article

DIANA-mirPath: Integrating human and mouse microRNAs in pathways

G. L. Papadopoulos, P. Alexiou, M. Maragkakis, M. Reczko and A. G. Hatzigeorgiou

in Bioinformatics

Volume 25, issue 15, pages 1991-1993
Published in print August 2009 | ISSN: 1367-4803
Published online May 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp299
DIANA-mirPath: Integrating human and mouse microRNAs in pathways

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Summary: DIANA-mirPath is a web-based computational tool developed to identify molecular pathways potentially altered by the expression of single or multiple microRNAs. The software performs an enrichment analysis of multiple microRNA target genes comparing each set of microRNA targets to all known KEGG pathways. The combinatorial effect of co-expressed microRNAs in the modulation of a given pathway is taken into account by the simultaneous analysis of multiple microRNAs. The graphical output of the program provides an overview of the parts of the pathway modulated by microRNAs, facilitating the interpretation and presentation of the analysis results.

Availability: The software is available at http://microrna.gr/mirpath and is free for all users with no login or download requirement.

Contact: papadopoulos@fleming.gr or hatzigeorgiou@fleming.gr

Journal Article.  1481 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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