Journal Article

TANDEM: integrating automated allele binning into genetics and genomics workflows

Michael Matschiner and Walter Salzburger

in Bioinformatics

Volume 25, issue 15, pages 1982-1983
Published in print August 2009 | ISSN: 1367-4803
Published online May 2009 | e-ISSN: 1460-2059 | DOI: https://dx.doi.org/10.1093/bioinformatics/btp303
TANDEM: integrating automated allele binning into genetics and genomics workflows

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Summary: Computer programs for the statistical analysis of microsatellite data use allele length variation to infer, e.g. population genetic parameters, to detect quantitative trait loci or selective sweeps. However, observed allele lengths are usually inaccurate and may deviate from the expected periodicity of repeats. The common practice of rounding to the nearest whole number frequently results in miscalls and underestimations of allelic richness. Manual sorting of allele lengths into discrete classes, a process called binning, is tedious and error-prone. Here, we present a new program for the automated binning of microsatellite allele lengths to overcome these problems and to facilitate high-throughput allele binning.

Availability: www.evolution.unibas.ch/salzburger/software.htm

Contact: michael.matschiner@unibas.ch

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  1363 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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