Journal Article

FlexServ: an integrated tool for the analysis of protein flexibility

Jordi Camps, Oliver Carrillo, Agustí Emperador, Laura Orellana, Adam Hospital, Manuel Rueda, Damjan Cicin-Sain, Marco D'Abramo, Josep Lluís Gelpí and Modesto Orozco

in Bioinformatics

Volume 25, issue 13, pages 1709-1710
Published in print July 2009 | ISSN: 1367-4803
Published online May 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp304
FlexServ: an integrated tool for the analysis of protein flexibility

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Summary: FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann's indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics.

Availability: http://mmb.pcb.ub.es/FlexServ; http://www.inab.org

Contact: modesto@mmb.pcb.ub.es or gelpi@mmb.pcb.ub.es

Supplementary information: Additional information and methodology details can be found at http://mmb.pcb.ub.es/FlexServ/help.

Journal Article.  1334 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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