Journal Article

Modeling multi-cellular behavior in epidermal tissue homeostasis via finite state machines in multi-agent systems

Thomas Sütterlin, Simone Huber, Hartmut Dickhaus and Niels Grabe

in Bioinformatics

Volume 25, issue 16, pages 2057-2063
Published in print August 2009 | ISSN: 1367-4803
Published online June 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp361
Modeling multi-cellular behavior in epidermal tissue homeostasis via finite state machines in multi-agent systems

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Motivation: For the efficient application of multi-agent systems to spatial and functional modeling of tissues flexible and intuitive modeling tools are needed, which allow the graphical specification of cellular behavior in a tissue context without presuming specialized programming skills.

Results: We developed a graphical modeling system for multi-agent based simulation of tissue homeostasis. An editor allows the intuitive and hierarchically structured specification of cellular behavior. The models are then automatically compiled into highly efficient source code and dynamically linked to an interactive graphical simulation environment. The system allows the quantitative analysis of the morphological and functional tissue properties emerging from the cell behavioral model. We demonstrate the relevance of the approach using a recently published model of epidermal homeostasis as well as a series of cell-cycle models.

Availability: The complete software is available in binary executables for MS-Windows and Linux at tiga.uni-hd.de

Contact: niels.grabe@bioquant.uni-heidelberg.de

Journal Article.  5277 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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