Journal Article

ITM Probe: analyzing information flow in protein networks

Aleksandar Stojmirović and Yi-Kuo Yu

in Bioinformatics

Volume 25, issue 18, pages 2447-2449
Published in print September 2009 | ISSN: 1367-4803
Published online June 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp398

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Summary: Founded upon diffusion with damping, ITM Probe is an application for modeling information flow in protein interaction networks without prior restriction to the sub-network of interest. Given a context consisting of desired origins and destinations of information, ITM Probe returns the set of most relevant proteins with weights and a graphical representation of the corresponding sub-network. With a click, the user may send the resulting protein list for enrichment analysis to facilitate hypothesis formation or confirmation.

Availability: ITM Probe web service and documentation can be found at www.ncbi.nlm.nih.gov/CBBresearch/qmbp/mn/itm_probe

Contact: yyu@ncbi.nlm.nih.gov

Journal Article.  1538 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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