Journal Article

HI: haplotype improver using paired-end short reads

Quan Long, Daniel MacArthur, Zemin Ning and Chris Tyler-Smith

in Bioinformatics

Volume 25, issue 18, pages 2436-2437
Published in print September 2009 | ISSN: 1367-4803
Published online July 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp412

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Summary: We present a program to improve haplotype reconstruction by incorporating information from paired-end reads, and demonstrate its utility on simulated data. We find that given a fixed coverage, longer reads (implying fewer of them) are preferable.

Availability: The executable and user manual can be freely downloaded from ftp://ftp.sanger.ac.uk/pub/zn1/HI.

Contact: ql2@sanger.ac.uk

Journal Article.  1436 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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