Journal Article

aGEM: an integrative system for analyzing spatial-temporal gene-expression information

Natalia Jiménez-Lozano, Joan Segura, José Ramón Macías, Juanjo Vega and José María Carazo

in Bioinformatics

Volume 25, issue 19, pages 2566-2572
Published in print October 2009 | ISSN: 1367-4803
Published online July 2009 | e-ISSN: 1460-2059 | DOI:

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Motivation: The work presented here describes the ‘anatomical Gene-Expression Mapping (aGEM)’ Platform, a development conceived to integrate phenotypic information with the spatial and temporal distributions of genes expressed in the mouse. The aGEM Platform has been built by extending the Distributed Annotation System (DAS) protocol, which was originally designed to share genome annotations over the WWW. DAS is a client-server system in which a single client integrates information from multiple distributed servers.

Results: The aGEM Platform provides information to answer three main questions. (i) Which genes are expressed in a given mouse anatomical component? (ii) In which mouse anatomical structures are a given gene or set of genes expressed? And (iii) is there any correlation among these findings? Currently, this Platform includes several well-known mouse resources (EMAGE, GXD and GENSAT), hosting gene-expression data mostly obtained from in situ techniques together with a broad set of image-derived annotations.

Availability: The Platform is optimized for Firefox 3.0 and it is accessed through a friendly and intuitive display:


Supplementary information: Supplementary data are available at and and Bioinformatics online.

Journal Article.  5489 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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