Journal Article

DiProGB: the dinucleotide properties genome browser

Maik Friedel, Swetlana Nikolajewa, Jürgen Sühnel and Thomas Wilhelm

in Bioinformatics

Volume 25, issue 19, pages 2603-2604
Published in print October 2009 | ISSN: 1367-4803
Published online July 2009 | e-ISSN: 1460-2059 | DOI:

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Motivation: DiProGB is an easy to use new genome browser that encodes the primary nucleotide sequence by thermodynamical and geometrical dinucleotide properties. The nucleotide sequence is thus converted into a sequence graph. This visualization, supported by different graph manipulation options, facilitates genome analyses, because the human brain can process visual information better than textual information. Also, DiProGB can identify genomic regions where certain physical properties are more conserved than the nucleotide sequence itself. Most of the DiProGB tools can be applied to both, the primary nucleotide sequence and the sequence graph. They include motif and repeat searches as well as statistical analyses. DiProGB adds a new dimension to the common genome analysis approaches by taking into account the physical properties of DNA and RNA.

Availability and Implementation: Source code and binaries are freely available for download at, implemented in C++ and supported on MS Windows and Linux (using e.g. WineHQ).


Journal Article.  1053 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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