Journal Article

WEbcoli: an interactive and asynchronous web application for <i>in silico</i> design and analysis of genome-scale <i>E.coli</i> model

Tae-Sung Jung, Hock Chuan Yeo, Satty G. Reddy, Wan-Sup Cho and Dong-Yup Lee

in Bioinformatics

Volume 25, issue 21, pages 2850-2852
Published in print November 2009 | ISSN: 1367-4803
Published online August 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp496
WEbcoli: an interactive and asynchronous web application for in silico design and analysis of genome-scale E.coli model

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Summary: WEbcoli is a WEb application for in silico designing, analyzing and engineering Escherichia coli metabolism. It is devised and implemented using advanced web technologies, thereby leading to enhanced usability and dynamic web accessibility. As a main feature, the WEbcoli system provides a user-friendly rich web interface, allowing users to virtually design and synthesize mutant strains derived from the genome-scale wild-type E.coli model and to customize pathways of interest through a graph editor. In addition, constraints-based flux analysis can be conducted for quantifying metabolic fluxes and charactering the physiological and metabolic states under various genetic and/or environmental conditions.

Availability: WEbcoli is freely accessible at http://webcoli.org.

Contact: cheld@nus.edu.sg

Journal Article.  994 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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