Journal Article

SimCT: a generic tool to visualize ontology-based relationships for biological objects

Carl Herrmann, Sèverine Bérard and Laurent Tichit

in Bioinformatics

Volume 25, issue 23, pages 3197-3198
Published in print December 2009 | ISSN: 1367-4803
Published online September 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp553

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Summary: We present a web-based service, SimCT, which allows to graphically display the relationships between biological objects (e.g. genes or proteins) based on their annotations to a biomedical ontology. The result is presented as a tree of these objects, which can be viewed and explored through a specific java applet designed to highlight relevant features. Unlike the numerous tools that search for overrepresented terms, SimCT draws a simplified representation of biological terms present in the set of objects, and can be applied to any ontology for which annotation data is available. Being web-based, it does not require prior installation, and provides an intuitive, easy-to-use service.

Availability: http://tagc.univ-mrs.fr/SimCT

Contact: carl.herrmann@univmed.fr

Supplementary information: Supplementary data are available at Bioinformatics online

Journal Article.  1278 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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