Journal Article

Functionally guided alignment of protein interaction networks for module detection

Waqar Ali and Charlotte M. Deane

in Bioinformatics

Volume 25, issue 23, pages 3166-3173
Published in print December 2009 | ISSN: 1367-4803
Published online October 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp569

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Motivation: Functional module detection within protein interaction networks is a challenging problem due to the sparsity of data and presence of errors. Computational techniques for this task range from purely graph theoretical approaches involving single networks to alignment of multiple networks from several species. Current network alignment methods all rely on protein sequence similarity to map proteins across species.

Results: Here we carry out network alignment using a protein functional similarity measure. We show that using functional similarity to map proteins across species improves network alignment in terms of functional coherence and overlap with experimentally verified protein complexes. Moreover, the results from functional similarity-based network alignment display little overlap (<15%) with sequence similarity-based alignment. Our combined approach integrating sequence and function-based network alignment alongside graph clustering properties offers a 200% increase in coverage of experimental datasets and comparable accuracy to current network alignment methods.

Availability: Program binaries and source code is freely available at http://www.stats.ox.ac.uk/research/bioinfo/resources

Contact: ali@stats.ox.ac.uk

Supplementary Information: Supplementary data are available at Bioinformatics online.

Journal Article.  6119 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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