Journal Article

webMGR: an online tool for the multiple genome rearrangement problem

Chi Ho Lin, Hao Zhao, Sean Harry Lowcay, Atif Shahab and Guillaume Bourque

in Bioinformatics

Volume 26, issue 3, pages 408-410
Published in print February 2010 | ISSN: 1367-4803
Published online December 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp689
webMGR: an online tool for the multiple genome rearrangement problem

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Summary: The algorithm MGR enables the reconstruction of rearrangement phylogenies based on gene or synteny block order in multiple genomes. Although MGR has been successfully applied to study the evolution of different sets of species, its utilization has been hampered by the prohibitive running time for some applications. In the current work, we have designed new heuristics that significantly speed up the tool without compromising its accuracy. Moreover, we have developed a web server (webMGR) that includes elaborate web output to facilitate navigation through the results.

Availability: webMGR can be accessed via http://www.gis.a-star.edu.sg/~bourque. The source code of the improved standalone version of MGR is also freely available from the web site.

Contact: bourque@gis.a-star.edu.sg

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  1525 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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