Journal Article

GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development

Tin-Lap Lee, Yunmin Li, Hoi-Hung Cheung, Janek Claus, Sumeeta Singh, Chandan Sastry, Owen M. Rennert, Yun-Fai Chris Lau and Wai-Yee Chan

in Bioinformatics

Volume 26, issue 4, pages 585-586
Published in print February 2010 | ISSN: 1367-4803
Published online December 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp695
GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development

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Summary: Serial analysis of gene expression (SAGE) provides an alternative, with additional advantages, to microarray gene expression studies. GonadSAGE is the first publicly available web-based SAGE database on male gonad development that covers six male mouse embryonic gonad stages, including E10.5, E11.5, E12.5, E13.5, E15.5 and E17.5. The sequence coverage of each SAGE library is beyond 150K, ‘which is the most extensive sequence-based male gonadal transcriptome to date’. An interactive web interface with customizable parameters is provided for analyzing male gonad transcriptome information. Furthermore, the data can be visualized and analyzed with the other genomic features in the UCSC genome browser. It represents an integrated platform that leads to a better understanding of male gonad development, and allows discovery of related novel targets and regulatory pathways.

Availability: GonadSAGE is at http://gonadsage.nichd.nih.gov.

Contact: leetl@mail.nih.gov

Journal Article.  1295 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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