Journal Article

DCDB: Drug combination database

Yanbin Liu, Bin Hu, Chengxin Fu and Xin Chen

in Bioinformatics

Volume 26, issue 4, pages 587-588
Published in print February 2010 | ISSN: 1367-4803
Published online December 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp697
DCDB: Drug combination database

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Summary: Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combined therapies for better clinical efficacy and safety, especially in cases of complicated and refractory diseases. Innovative experimental technologies and theoretical frameworks are being actively developed for multicomponent drug research. In this work, we present the Drug Combination Database, with aims to facilitate analyses of known drug combinations, to summarize patterns of beneficial drug interactions, and to provide a basis for theoretical modeling and simulation of such drug interactions. Its current version (1.0) collected 499 approved or investigational drug combinations, including 40 unsuccessful drug combinations, involving 485 individual drugs, from >6000 references.

Availability: http://www.cls.zju.edu.cn/dcdb/.

Contact: xinchen@zju.edu.cn

Supplementary information: Supplementary data are available at the database website and Bioinformatics online.

Journal Article.  1271 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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