Journal Article

invertFREGENE: software for simulating inversions in population genetic data

Paul F. O'Reilly, Lachlan J. M. Coin and Clive J. Hoggart

in Bioinformatics

Volume 26, issue 6, pages 838-840
Published in print March 2010 | ISSN: 1367-4803
Published online January 2010 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btq029
invertFREGENE: software for simulating inversions in population genetic data

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Summary: Inversions are a common form of structural variation, which may have a marked effect on the genome and methods to infer quantities of interest such as those relating to population structure and natural selection. However, due to the challenge in detecting inversions, little is presently known about their impact. Software to simulate inversions could be used to provide a better understanding of how to detect and account for them; but while there are several software packages for simulating population genetic data, none incorporate inversion polymorphisms. Here, we describe a software package, modified from the forward-in-time simulator FREGENE, which simulates the evolution of an inversion polymorphism, of specified length, location, frequency and age, in a population of sequences. We describe previously unreported signatures of inversions in SNP data observed in invertFREGENE results and a known inversion in humans.

Availability: C++ source code and user manual are available for download from http://www.ebi.ac.uk/projects/BARGEN/ under the GPL licence.

Contact: l.coin@ic.ac.uk; c.hoggart@ic.ac.uk

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  1763 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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