Journal Article

iPHACE: integrative navigation in pharmacological space

Ricard Garcia-Serna, Oleg Ursu, Tudor I. Oprea and Jordi Mestres

in Bioinformatics

Volume 26, issue 7, pages 985-986
Published in print April 2010 | ISSN: 1367-4803
Published online February 2010 | e-ISSN: 1460-2059 | DOI:
iPHACE: integrative navigation in pharmacological space

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Summary: The increasing availability of experimentally determined binding affinities for drugs on multiple protein targets requires the design of specific mining and visualization tools that graphically integrate chemical and biological data in an efficient environment. With this aim, we developed iPHACE, an integrative web-based tool to navigate in the pharmacological space defined by small molecule drugs contained in the IUPHAR-DB, with additional interactions present in PDSP. Extending beyond traditional querying and filtering tools, iPHACE offers a means to extract knowledge from the target profile of drugs as well as from the drug profile of protein targets.

Availability: iPHACE is available at (EU site) and (US mirror)


Journal Article.  1255 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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