Journal Article

Treephyler: fast taxonomic profiling of metagenomes

Fabian Schreiber, Peter Gumrich, Rolf Daniel and Peter Meinicke

in Bioinformatics

Volume 26, issue 7, pages 960-961
Published in print April 2010 | ISSN: 1367-4803
Published online February 2010 | e-ISSN: 1460-2059 | DOI:
Treephyler: fast taxonomic profiling of metagenomes

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Summary: Assessment of phylogenetic diversity is a key element to the analysis of microbial communities. Tools are needed to handle next-generation sequencing data and to cope with the computational complexity of large-scale studies. Here, we present Treephyler, a tool for fast taxonomic profiling of metagenomes. Treephyler was evaluated on real metagenome to assess its performance in comparison to previous approaches for taxonomic profiling. Results indicate that Treephyler is in terms of speed and accuracy prepared for next-generation sequencing techniques and large-scale analysis.

Availability: Treephyler is implemented in Perl; it is portable to all platforms and applicable to both nucleotide and protein input data. Treephyler is freely available for download at


Journal Article.  1311 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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