Journal Article

DASS-GUI: a user interface for identification and analysis of significant patterns in non-sequential data

Jens Hollunder, Maik Friedel, Martin Kuiper and Thomas Wilhelm

in Bioinformatics

Volume 26, issue 7, pages 987-989
Published in print April 2010 | ISSN: 1367-4803
Published online February 2010 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btq071

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Summary: Many large ‘omics’ datasets have been published and many more are expected in the near future. New analysis methods are needed for best exploitation. We have developed a graphical user interface (GUI) for easy data analysis. Our discovery of all significant substructures (DASS) approach elucidates the underlying modularity, a typical feature of complex biological data. It is related to biclustering and other data mining approaches. Importantly, DASS-GUI also allows handling of multi-sets and calculation of statistical significances. DASS-GUI contains tools for further analysis of the identified patterns: analysis of the pattern hierarchy, enrichment analysis, module validation, analysis of additional numerical data, easy handling of synonymous names, clustering, filtering and merging. Different export options allow easy usage of additional tools such as Cytoscape.

Availability: Source code, pre-compiled binaries for different systems, a comprehensive tutorial, case studies and many additional datasets are freely available at http://www.ifr.ac.uk/dass/gui/. DASS-GUI is implemented in Qt.

Contact: jehol@psb.vib-ugent.be; thomas.wilhelm@bbsrc.ac.uk

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  1242 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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