Journal Article

TiSGeD: a database for tissue-specific genes

Sheng-Jian Xiao, Chi Zhang, Quan Zou and Zhi-Liang Ji

in Bioinformatics

Volume 26, issue 9, pages 1273-1275
Published in print May 2010 | ISSN: 1367-4803
Published online March 2010 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btq109

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Summary: The tissue-specific genes are a group of genes whose function and expression are preferred in one or several tissues/cell types. Identification of these genes helps better understanding of tissue–gene relationship, etiology and discovery of novel tissue-specific drug targets. In this study, a statistical method is introduced to detect tissue-specific genes from more than 123 125 gene expression profiles over 107 human tissues, 67 mouse tissues and 30 rat tissues. As a result, a novel subject-specialized repository, namely the tissue-specific genes database (TiSGeD), is developed to represent the analyzed results. Auxiliary information of tissue-specific genes was also collected from biomedical literatures.

Availability: http://bioinf.xmu.edu.cn/databases/TiSGeD/index.html

Contact: appo@bioinf.xmu.edu.cn; zhiliang.ji@gmail.com

Journal Article.  1927 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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