Journal Article

varLD: a program for quantifying variation in linkage disequilibrium patterns between populations

Rick Twee-Hee Ong and Yik-Ying Teo

in Bioinformatics

Volume 26, issue 9, pages 1269-1270
Published in print May 2010 | ISSN: 1367-4803
Published online March 2010 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btq125
varLD: a program for quantifying variation in linkage disequilibrium patterns between populations

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Motivation: Linkage disequilibrium (LD) differences between populations can potentially result in failure to replicate primary signals of trait association in independent genome-wide association studies (GWAS). However, such inter-population LD differences can be leveraged to narrow the search for common causal variants responsible for the association signals observed. The ability to assess and quantify LD variations among populations is thus expected to contribute to both replication and fine-mapping stages of GWAS.

Availability: The program varLD is available for download from http://www.nus-cme.org.sg/software/varld.html

Contact: statyy@nus.edu.sg

Journal Article.  1459 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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