Journal Article

IntSide: a web server for the chemical and biological examination of drug side effects

Teresa Juan-Blanco, Miquel Duran-Frigola and Patrick Aloy

in Bioinformatics

Volume 31, issue 4, pages 612-613
Published in print February 2015 | ISSN: 1367-4803
Published online November 2014 | e-ISSN: 1460-2059 | DOI:
IntSide: a web server for the chemical and biological examination of drug side effects

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Summary: Drug side effects are one of the main health threats worldwide, and an important obstacle in drug development. Understanding how adverse reactions occur requires knowledge on drug mechanisms at the molecular level. Despite recent advances, the need for tools and methods that facilitate side effect anticipation still remains. Here, we present IntSide, a web server that integrates chemical and biological information to elucidate the molecular mechanisms underlying drug side effects. IntSide currently catalogs 1175 side effects caused by 996 drugs, associated with drug features divided into eight categories, belonging to either biology or chemistry. On the biological side, IntSide reports drug targets and off-targets, pathways, molecular functions and biological processes. From a chemical viewpoint, it includes molecular fingerprints, scaffolds and chemical entities. Finally, we also integrate additional biological data, such as protein interactions and disease-related genes, to facilitate mechanistic interpretations.

Availability and implementation: Our data and web resource are available online (


Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  1066 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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