Journal Article

Characterization of clinical signs in the human interactome

Monica Chagoyen and Florencio Pazos

in Bioinformatics

Volume 32, issue 12, pages 1761-1765
Published in print June 2016 | ISSN: 1367-4803
Published online February 2016 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btw054
Characterization of clinical signs in the human interactome

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Motivation: Many diseases are related by shared associated molecules and pathways, exhibiting comorbidities and common phenotypes, an indication of the continuous nature of the human pathological landscape. Although it is continuous, this landscape is always partitioned into discrete diseases when studied at the molecular level. Clinical signs are also important phenotypic descriptors that can reveal the molecular mechanisms that underlie pathological states, but have seldom been the subject of systemic research. Here, we quantify the modular nature of the clinical signs associated with genetic diseases in the human interactome.

Results: We found that clinical signs are reflected as modules at the molecular network level, to at least to the same extent as diseases. They can thus serve as a valid complementary partition of the human pathological landscape, with implications for etiology research, diagnosis and treatment.

Contact: monica.chagoyen@cnb.csic.es

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  2936 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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