Journal Article

Effects of dexamethasone on clinical course, C‐reactive protein, S100B protein and von Willebrand factor antigen after paediatric cardiac surgery

L. Lindberg, C. Forsell, P. Jögi and A.‐K. Olsson

in BJA: British Journal of Anaesthesia

Published on behalf of the British Journal of Anaesthesia

Volume 90, issue 6, pages 728-732
Published in print June 2003 | ISSN: 0007-0912
Published online June 2003 | e-ISSN: 1471-6771 | DOI: http://dx.doi.org/10.1093/bja/aeg125
Effects of dexamethasone on clinical course, C‐reactive protein, S100B protein and von Willebrand factor antigen after paediatric cardiac surgery

Show Summary Details

Preview

Background. Anti‐inflammatory treatment with glucocorticoids during cardiopulmonary bypass can reduce inflammatory mediator release, but the effects of glucocorticoid on outcome are controversial.

Methods. We studied the effects of dexamethasone on clinical course, C‐reactive protein, von Willebrand factor antigen (vWf:Ag) and S100B in a randomized masked study of children after open cardiac surgery. Twenty children weighing >10 kg received dexamethasone (1 mg kg–1) and 20 controls received saline after induction of anaesthesia. We measured vWf:Ag as a marker of endothelial activation, S100B as a marker of cerebral protein release and C‐reactive protein as a marker of inflammatory activity. Oxygenation, body temperature, fluid balance, leucocyte and platelet counts, days in the intensive care unit (ICU) and days on mechanical ventilation were noted.

Results. Dexamethasone decreased C‐reactive protein concentration on the first postoperative day (P<0.05), but did not affect the release of vWf:Ag or S100B. There was no significant difference in oxygenation, body temperature, fluid balance, leucocyte and platelet counts, days in the ICU or days on mechanical ventilation between the placebo and dexamethasone‐treated groups.

Conclusion. Administration of dexamethasone before cardiopulmonary bypass for paediatric cardiac surgery decreased the inflammatory response, but did not affect the immediate features after surgery or changes in vWf:Ag or S100B.

Br J Anaesth 2003; 90: 728–32

Keywords: Keywords: heart, cardiopulmonary bypass; hormones, corticosteroid; surgery, cardiovascular

Journal Article.  3119 words.  Illustrated.

Subjects: Anaesthetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.