Journal Article

Countering Kauffman with Connectionism: Two Views of Gene Regulation and the Fundamental Nature of Ontogeny

Roger Sansom

in The British Journal for the Philosophy of Science

Published on behalf of British Society for the Philosophy of Science

Volume 59, issue 2, pages 169-200
Published in print June 2008 | ISSN: 0007-0882
Published online June 2008 | e-ISSN: 1464-3537 | DOI: http://dx.doi.org/10.1093/bjps/axn005
Countering Kauffman with Connectionism: Two Views of Gene Regulation and the Fundamental Nature of Ontogeny

More Like This

Show all results sharing these subjects:

  • Philosophy of Science
  • Science and Mathematics

GO

Show Summary Details

Preview

Understanding the operation and evolution of gene regulation networks is critical to understanding ontogeny and evolution. According to Stuart Kauffman's view, (1) each cell type cycles through its own repeated pattern of gene expression, (2) the order of ontogeny is dependent on these cycles being short, and (3) evolution is possible because these cycles mutate gradually. This view of gene regulation reflects Kauffman's view that ontogeny is fundamentally the process of cells repeating cycles of activity. I criticize Kauffman's view of gene regulation networks and offer the connectionist theory of gene regulation as an alternative. On this view, the generic order of gene regulation mechanisms is due to the qualitatively consistent way that one gene product influences the expression of another. This allows networks to be stable and evolve to regulate accurately, allowing cells to react appropriately to their microenvironments, due to design by natural selection.

Introduction

Kauffman's Model of Gene Regulation

Explaining the Order of Kauffman's K = 2 Networks

The Importance and Relevance of Kauffman's Explanations of the Order of Gene Regulation

Additional Orderly Facts of Transcription

The Order of Network Accuracy

The Accuracy of Connectionist Networks

The Evolvability of Gene Regulation Networks

Laws of Structure

Journal Article.  11914 words.  Illustrated.

Subjects: Philosophy of Science ; Science and Mathematics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.