Journal Article

Somatotopic motor representation in the human anterior cerebellum

Matthias F.Nitschke, Andreas Kleinschmidt, Karl Wessel and Jens Frahm

in Brain

Published on behalf of The Guarantors of Brain

Volume 119, issue 3, pages 1023-1029
Published in print June 1996 | ISSN: 0006-8950
Published online June 1996 | e-ISSN: 1460-2156 | DOI: https://dx.doi.org/10.1093/brain/119.3.1023
Somatotopic motor representation in the human anterior cerebellum

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Summary

Though somatotopic encoding of function is a prominent feature in brain structures involved in sensori-motor processing. it has not been well established for the human cerebellum. We delineated the representation of hand, foot and tongue movements in the anterior cerebellar lobe of eight healthy subjects using dynamic high-resolution MRI sensitized to changes in cerebral blood oxygenation(CBO). Activation was determined by pixel-by-pixel correlation of signal intensity time courses with the performance protocol. All subjects showed task-related signal increases in anipsilateral region during distal limb movements. For the hand task, the centre of activation was located in the intermediate hemispheric portion of Larsell lobules H IV–V. Foot movements activated areas within the central lobule, Larsell lobules II-III, medial and anterior to the corresponding hand areas in all subjects. Responses for tongue movements were less consistent across subjects but found in areas posterior to the respective individual hand representation.

Keywords: human cerebellum; motor control; functional activation; MRI; neuroimaging

Journal Article.  0 words. 

Subjects: Neurology ; Neuroscience

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