Journal Article

Cortical and subcortical contributions to ideomotor apraxia

Brenda Hanna-Pladdy, Kenneth M. Heilman and Anne L. Foundas

in Brain

Published on behalf of The Guarantors of Brain

Volume 124, issue 12, pages 2513-2527
Published in print December 2001 | ISSN: 0006-8950
Published online December 2001 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/124.12.2513
Cortical and subcortical contributions to ideomotor apraxia

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Ideomotor apraxia (IMA) is often associated with damage of the dominant parietal cortex, but many other lesion sites have been implicated suggesting that the praxis system is mediated by a distributed modular network. Although IMA has been reported with subcortical lesions, the role of subcortical structures in the praxis neural network has not been fully addressed. To ascertain the role of subcortical structures in praxis, we compared praxis performance on a variety of tasks in patients with left hemisphere cortical and subcortical lesions. The cortical patients presented with deficits in the production of transitive and intransitive gestures-to-verbal command and imitation, as well as impaired gesture discrimination. In contrast, the subcortical group demonstrated mild production-execution deficits for transitive pantomimes, but normal imitation and discrimination. Qualitative error analysis of production deficits, revealed that both patient groups produced timing errors and the full range of spatial errors. Whereas the subcortical group made more postural errors than the cortical group, sequencing, unrecognizable and no-response errors were only produced by the cortical group. The different profiles of praxis deficits associated with cortical and subcortical lesions, suggests that these structures may have different roles in praxis.

Keywords: apraxia; ideomotor; limb; basal ganglia; motor control; ANOVA = analysis of variance; AQ = aphasia quotient; BPT = body part as tool; CD = cortical damage; IMA = ideomotor apraxia; MANOVA = multivariate analysis of variance; SCD = subcortical damage; WAB = Western Aphasia Battery

Journal Article.  11742 words. 

Subjects: Neurology ; Neuroscience

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