Journal Article

Brain abnormalities underlying altered activation in dyslexia: a voxel based morphometry study

G. Silani, U. Frith, J.-F. Demonet, F. Fazio, D. Perani, C. Price, C. D. Frith and E. Paulesu

in Brain

Published on behalf of The Guarantors of Brain

Volume 128, issue 10, pages 2453-2461
Published in print October 2005 | ISSN: 0006-8950
Published online June 2005 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/awh579
Brain abnormalities underlying altered activation in dyslexia: a voxel based morphometry study

Show Summary Details

Preview

Voxel-based morphometry was used to assess the consistency among functional imaging and brain morphometry data in developmental dyslexia. Subjects, from three different cultural contexts (UK, France and Italy), were the same as those described in a previous PET activation paper, which revealed a common pattern of reduced activation during reading tasks in the left temporal and occipital lobes. We provide evidence that altered activation observed within the reading system is associated with altered density of grey and white matter of specific brain regions, such as the left middle and inferior temporal gyri and the left arcuate fasciculus. This supports the view that dyslexia is associated with both local grey matter dysfunction and with altered connectivity among phonological/reading areas. The differences were replicable across samples confirming that the neurological disorder underlying dyslexia is the same across the cultures investigated in the study.

Keywords: developmental dyslexia; MRI; PET; cultural context; phonological deficit; disconnection hypothesis; grey matter; white matter; VBM = voxel-based morphometry

Journal Article.  6178 words.  Illustrated.

Subjects: Neurology ; Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.