Journal Article

Brain stimulation reveals critical auditory naming cortex

Marla J. Hamberger, William T. Seidel, Guy M. Mckhann, Kenneth Perrine and Robert R. Goodman

in Brain

Published on behalf of The Guarantors of Brain

Volume 128, issue 11, pages 2742-2749
Published in print November 2005 | ISSN: 0006-8950
Published online August 2005 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/awh621
Brain stimulation reveals critical auditory naming cortex

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One challenge in dominant temporal lobe epilepsy surgery is to remove sufficient epileptogenic tissue without compromising post-operative language functioning. Pre-resection electrical stimulation mapping enables identification of language areas that can be spared from resection, and also provides a unique opportunity to investigate brain–language relationships. Visual object naming is the gold standard for identifying ‘essential’ language cortex; however, sparing visual naming (VN) sites has not reliably prevented post-operative language decline. In addition to visual object naming, we included a more ‘ecologically valid’ auditory description naming task in our pre-resection cortical mapping protocol. Of the seven patients who had auditory naming (AN) sites removed, six declined post-operatively, whereas of the 12 patients who did not have AN sites removed, only 3 declined post-operatively (P = 0.02), suggesting an association between AN site removal and post-operative naming decline. Interestingly, although VN sites were preserved in all patients, AN site removal resulted in decline in both auditory and VN tasks. These findings not only have potentially critical clinical significance, but also argue for modality specificity, with considerable integration within the semantic system.

Keywords: language mapping; naming; cortical stimulation; AN = auditory naming; ANT = auditory naming test; MTS = medial temporal sclerosis; RCI = reliable change index; TLE = temporal lobe epilepsy; TOT = tip-of-the-tongue; VN = visual naming; VNT = visual naming test

Journal Article.  5862 words. 

Subjects: Neurology ; Neuroscience

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