Journal Article

Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Aβ amyloid pathway

Colin L. Masters and Konrad Beyreuther

in Brain

Published on behalf of The Guarantors of Brain

Volume 129, issue 11, pages 2823-2839
ISSN: 0006-8950
Published online September 2006 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/awl251
Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Aβ amyloid pathway

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It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the first 80 years, very little progress was made in understanding the mechanisms that caused the brain to degenerate in a remarkably specific fashion (amyloid accumulation with neurofibrillary changes). Over the past 20 years, there has been an explosion of knowledge which continues today at an exponential rate. The molecular pathways underlying the synaptic dysfunction in Alzheimer's disease have delivered many validated therapeutic and diagnostic targets. A variety of therapeutic strategies aimed at disease modification are now in clinical development.

Keywords: Aβ amyloid pathway; Alzheimer's disease; amyloid beta precursor protein

Journal Article.  10418 words.  Illustrated.

Subjects: Neurology ; Neuroscience

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