Journal Article

Auditory cortical activity in amnestic mild cognitive impairment: relationship to subtype and conversion to dementia

Edward J. Golob, Rie Irimajiri and Arnold Starr

in Brain

Published on behalf of The Guarantors of Brain

Volume 130, issue 3, pages 740-752
Published in print March 2007 | ISSN: 0006-8950
Published online February 2007 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/awl375
Auditory cortical activity in amnestic mild cognitive impairment: relationship to subtype and conversion to dementia

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Mild cognitive impairment (MCI) patients have a high risk of converting to Alzheimer's disease. The most common diagnostic subtypes of MCI have an episodic memory disorder (amnestic MCI) occurring either alone [single domain (SD)] or with other cognitive impairments [multiple domain (MD)]. Previous studies report increased amplitudes of auditory cortical potentials in MCI, but their relationships to MCI subtypes and clinical outcomes were not defined. We studied subjects with amnestic MCI (n = 41: 28 SD, 13 MD), Alzheimer's disease (n = 14), and both younger (n = 22) and age-matched older controls (n = 44). Baseline auditory sensory (P50, N100) and cognitive potentials (P300) were recorded during an auditory discrimination task. MCI patients were followed for up to 5 years, and outcomes were classified as (i) continued diagnosis of MCI (MCI-stable, n = 16), (ii) probable Alzheimer's disease (MCI-convert, n = 18), or other outcomes (n = 7). Auditory potentials were analysed as a function of MCI diagnosis and outcomes, and compared with young, older controls, and mild Alzheimer's disease subjects. P50 amplitude increased with normal ageing, and had additional increases in MCI as a function of both initial diagnosis (MD > than SD) and outcome (MCI-convert > MCI-stable). P300 latency increased with normal ageing, and had additional increases in MCI but did not differ among outcomes. We conclude that auditory cortical sensory potentials differ among amnestic MCI subtypes and outcomes occurring up to 5 years later.

Keywords: MCI; single domain; multiple domain; event-related potentials; EEG

Journal Article.  8960 words.  Illustrated.

Subjects: Neurology ; Neuroscience

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