Journal Article

Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy

Bernd Weber, Eileen Luders, Jennifer Faber, Sabine Richter, Carlos M. Quesada, Horst Urbach, Paul M. Thompson, Arthur W. Toga, Christian E. Elger and Christoph Helmstaedter

in Brain

Published on behalf of The Guarantors of Brain

Volume 130, issue 12, pages 3149-3154
Published in print December 2007 | ISSN: 0006-8950
Published online August 2007 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/awm186
Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy

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We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.

Keywords: corpus callosum; temporal lobe epilepsy; MRI

Journal Article.  3100 words.  Illustrated.

Subjects: Neurology ; Neuroscience

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