Journal Article

Chromosomal profiles of gene expression in Huntington's disease

Alexander N. Anderson, Federico Roncaroli, Angela Hodges, Manuel Deprez and Federico E. Turkheimer

in Brain

Published on behalf of The Guarantors of Brain

Volume 131, issue 2, pages 381-388
Published in print February 2008 | ISSN: 0006-8950
Published online December 2007 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/awm312
Chromosomal profiles of gene expression in Huntington's disease

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Recent studies suggested that Huntington's disease is due to aberrant interactions between mutant huntingtin protein, transcription factors and transcriptional co-activators resulting in widespread transcriptional dysregulation. Mutant huntingtin also interacts with histone acetyltransferases, consequently interfering with the acetylation and deacetylation states of histones. Because histone modifications and chromatin structure coordinate the expression of gene clusters, we have applied a novel mathematical approach, Chromowave, to analyse microarray datasets of brain tissue and whole blood to understand how genomic regions are altered by the effects of mutated huntingtin on chromatin structure. Results show that, in samples of caudate and whole blood from Huntington's disease patients, transcription is indeed deregulated in large genomic regions in coordinated fashion, that transcription in these regions is associated with disease progression and that altered chromosomal clusters in the two tissues are remarkably similar. These findings support the notion of a common genome-wide mechanism of disruption of RNA transcription in the brain and periphery of Huntington's disease patients.

Keywords: Huntington's disease; microarrays; histone deacetylase; chromosomal expression; Chromowave

Journal Article.  3474 words.  Illustrated.

Subjects: Neurology ; Neuroscience

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