Journal Article

Focal basal ganglia lesions are associated with impairments in reward-based reversal learning

Christian Bellebaum, Benno Koch, Michael Schwarz and Irene Daum

in Brain

Published on behalf of The Guarantors of Brain

Volume 131, issue 3, pages 829-841
Published in print March 2008 | ISSN: 0006-8950
Published online February 2008 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/awn011
Focal basal ganglia lesions are associated with impairments in reward-based reversal learning

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The basal ganglia (BG) are thought to play a key role in learning from feedback, with mesencephalic dopamine neurons coding errors in reward prediction, thereby mediating information processing in the BG and the prefrontal cortex. In the present study, reward-based learning was assessed in patients with focal BG lesions, by studying outcome-based acquisition and reversal of stimulus–stimulus associations with different reward magnitudes in two probabilistic learning tasks. Eleven patients with selective BG lesions (three females) and 18 healthy control subjects (six females) participated in this study. Two cognitive transfer tasks provided a measure of declarative learning strategy application. On the group level, BG patients showed deficits in reversal learning, with dorsal striatum lesion patients being most severely affected. While basic mechanisms of learning from feedback such as the processing of different reward magnitudes appeared to be intact, patients needed more trials than controls to learn a second reward-based task, suggesting reduced carry-over effects in learning. A patient with a bilateral BG lesion showed better performance than controls on most learning tasks, applying a compensatory declarative learning strategy. The results are discussed in terms of the implication of different BG subregions in different aspects of learning from feedback.

Keywords: reward; basal ganglia; striatum; learning; reversal

Journal Article.  9141 words.  Illustrated.

Subjects: Neurology ; Neuroscience

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