Journal Article

The complex genetics of multiple sclerosis: pitfalls and prospects

Stephen Sawcer

in Brain

Published on behalf of The Guarantors of Brain

Volume 131, issue 12, pages 3118-3131
Published in print December 2008 | ISSN: 0006-8950
Published online May 2008 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/awn081

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Preview

The genetics of complex disease is entering a new and exciting era. The exponentially growing knowledge and technological capabilities emerging from the human genome project have finally reached the point where relevant genes can be readily and affordably identified. As a result, the last 12 months has seen a virtual explosion in new knowledge with reports of unequivocal association to relevant genes appearing almost weekly. The impact of these new discoveries in Neuroscience is incalculable at this stage but potentially revolutionary. In this review, an attempt is made to illuminate some of the mysteries surrounding complex genetics. Although focused almost exclusively on multiple sclerosis all the points made are essentially generic and apply equally well, with relatively minor addendums, to any other complex trait, neurological or otherwise.

Keywords: multiple sclerosis; genetics; association; linkage

Journal Article.  10196 words.  Illustrated.

Subjects: Neurology ; Neuroscience

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