Journal Article

Cytogenetic effects of occupational exposure in the peripheral blood lymphocytes of pesticide sprayers

Anastasions Kourakis, Maria Mouratidou, Aikaterini Barbouti and Maria Dimikiotou

in Carcinogenesis

Volume 17, issue 1, pages 99-101
Published in print January 1996 | ISSN: 0143-3334
e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.1.99
Cytogenetic effects of occupational exposure in the peripheral blood lymphocytes of pesticide sprayers

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The potential clastogenic effect of pesticides was investigated in 56 (29 indoor and 27 outdoor) agricultural workers exposed to complex chemical mixtures. Exposed and referent subjects were selected from the same geographical area located in Ionia, province of Thessaloniki, Greece. Chromosome aberrations (CA) and sister chromatid exchanges (SCE), were studied in peripheral lymphocytes. Comparison between workers and control group revealed that the individuals exposed to pesticieds showed substantial clastogenic effects (CA = 2.66% compared to 0.53%, P <0.001), in their Lymphocytes without indication of increases in their basal frequency of SCE. Moreover, the condition of exposure has been found to influence the CA frequency. It was observed that individuals working exclusively in greenhouses (confined spaces) showed higher CA levels than subjects working in open fields(3.37 versus 1.88, P <0.01). No significant difference in their expression of CA between smokers and non-smokers was found. The present chromosome study included workers living in the close vincinity of a large industrial zone near Thessaloniki. The percentage of CA in these indoor sprayers was higher compared to our previous study carried out in a different area of Thesaloniki, free of industrial plants (3.37% compared to 2.14%, P <0.02).

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Subjects: Clinical Cytogenetics and Molecular Genetics

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