Journal Article

ACCELERATED PAPER: Lack of association between the polyadenylation polymorphism in the <i>NATl</i> (acetyltransferase 1) gene and colorectal adenomas

Nicole M. Probst-Hensch, Robert W. Haile, Donna S. Li, Gordon T. Sakamoto, Andrew D. Louie, Bruce K. Lin, Harold D. Frankl, Eric R. Lee and Henry J. Lin

in Carcinogenesis

Volume 17, issue 10, pages 2125-2129
Published in print October 1996 | ISSN: 0143-3334
Published online October 1996 | e-ISSN: 1460-2180 | DOI: https://dx.doi.org/10.1093/carcin/17.10.2125
ACCELERATED PAPER: Lack of association between the polyadenylation
                    polymorphism in the NATl (acetyltransferase 1) gene and
                    colorectal adenomas

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Smoking and a high intake of red meat are risk factors for colorectal tumors. These effects could be due to aromatic amine carcinogens. Individual susceptibility to aromatic amines has been related to acetylation phenotype, which plays a role in the bioactivation of arylamines. Polymorphisms in both N-acetyltransferase genes, NAT1 and NAT2, have been associated with an increased risk of colorectal tumors. We studied the NATl*10 fast acetylator allele (1088 T→A mutation) and distal adenomas in a sigmoido-scopy-based case-control study (441 cases, 484 controls). We found neither an increased adenoma prevalence in subjects homozygous or heterozygous for the NATl*10 fast acetylator allele (odds ratio 1.04; 95% confidence interval 0.79–1.36), nor a gene-gene interaction between NA1 and NAT2 (Pinteraction = 0.59). Further NAT1 alleles must be considered for more conclusive results regarding the relevance of NAT1 activity to colorectal tumorigenesis.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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