Journal Article

Expression of receptors for gut peptides in pancreata of BOP-treated and control hamsters

Chengwei Tang, Izãk Biemond, Marko J. Appel, Corjan J.T. Visser, Ruud A. Woutersen and Cornelis B.H.W. Lamers

in Carcinogenesis

Volume 17, issue 10, pages 2171-2175
Published in print October 1996 | ISSN: 0143-3334
Published online October 1996 | e-ISSN: 1460-2180 | DOI:
Expression of receptors for gut peptides in pancreata of BOP-treated
                    and control hamsters

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The growth of pancreatic cancers may be influenced by certain gut peptides. However, the alteration of gut peptide receptors in the progress of pancreatic carcino-genesis is largely unknown. With storage phosphor auto-radiography, this study visualized and characterized receptors for cholecystokinin (CCK), somatostatin (SST), bombesin (BBS), secretin and vasoactive intestinal peptide (VIP) in pancreata of control hamsters (n = 7) and pancreatic preneoplastic lesions (n = 10) or adeno-carcinomas (n=10) of N-nitrosobis(2-oxopropyl)amine (BOP)-treated hamsters. The specific CCK-A and secretin receptors expressed in normal pancreata were markedly reduced in pancreatic preneoplastic lesions and absent in adenocarcinomas. In the development of pancreatic tumours, the subgroup of SST receptors did not change, but both the affinity and binding capacity declined. In comparison with the binding of VIP to normal pancreata, specific VIP binding was significantly lower in preneo-plastic lesions and almost absent in pancreatic adeno-carcinomas. No specific binding for BBS was detected in normal pancreas or (pre)neoplastic lesions of hamster pancreas. The reduction or absence of receptors for CCK, secretin, SST and VIP in hamster pancreas with the progress of carcinogenesis suggests that in BOP-treated hamsters, pancreatic adenocarcinomas have, to a large extent, lost the hormone-dependent characteristics of the original tissue.

Journal Article.  0 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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