Journal Article

Hemoglobin adducts of benzo[<i>a</i>]pyrene diolepoxide in newspaper vendors: association with traffic exhaust

Roberta Pastorelli, Jolanda Restano, Marco Guanci, Monica Maramonte, Cinzia Magagnotti, Riccardo Allevi, Davide Lauri, Roberto Fanelli and Luisa Airoldi

in Carcinogenesis

Volume 17, issue 11, pages 2389-2394
Published in print November 1996 | ISSN: 0143-3334
Published online November 1996 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.11.2389
Hemoglobin adducts of benzo[a]pyrene diolepoxide in
                    newspaper vendors: association with traffic exhaust

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Benzo[a]pyrene diol epoxide adducts with hemoglobin (Hb) were measured to detect human exposure to environmental benzo[a]pyrene from traffic exhaust. Benzo[a]pyrene tetrahydrotetrols (BPTs) released from Hb after acid hydrolysis were quantitated by gas chromatography-mass spectrometry after immunoaffinity chromatography. Fifty three newspaper vendors were enrolled. The median adduct concentration was 0.3 fmol BPTs/mg Hb in high density traffic-exposed vendors and ≤0.1 fmol BPTs/mg Hb in those exposed to low density traffic; the difference was not significant (P = 0.09). Among non-smokers, adducts were detectable in 60% of high exposure subjects (median 0.3 fmol BPTs/mg Hb) and in 28% of those with low exposure (median ≤0.1 fmol/mg Hb). This difference was significant (P = 0.02). In low exposure smokers the median of adducts was 0.26 fmol BPTs/mg Hb, while in low exposure non-smokers it was ≤0.1 fmol BPTs/mg Hb (P = 0.08, not significant). Adduct concentration was no different for low and high density traffic-exposed smokers (P = 0.82). The data indicate a significant difference in adduct concentration related to traffic exhaust exposure among non-smokers.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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