Journal Article

Genetics of chemical carcinogenesis—III. Tissue-specificity of the genes controlling susceptibility and resistance to skin carcinogenesis in the mouse

Anna Saran, Yolande Bouthillier, Claudio Pioli, Denise Mouton, Vincenzo Covelli, Gino Doria, Therese Neveu and Guido Biozzi

in Carcinogenesis

Volume 17, issue 11, pages 2463-2468
Published in print November 1996 | ISSN: 0143-3334
Published online November 1996 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.11.2463
Genetics of chemical carcinogenesis—III. Tissue-specificity of
                    the genes controlling susceptibility and resistance to skin carcinogenesis in
                    the mouse

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Carcinogenesis-resistant (Car-R) and carcinogenesis-susceptible (Car-S) mice have been obtained by the method of bi-directional selective breeding. After 10 generations of selection Car-R and Car-S mice show a remarkable difference in their response to chemical carcinogenesis. Car-R and Car-S mice, initiated and promoted by skin application of 9, 10-dimethyl-1,2-benzanthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) reach a tumour multiplicity of 0.05 and 6.2, respectively, after 49 days of promotion. When benzo[a]pyrene (B[a]P) is topically applied for initiation, followed by TPA promotion, Car-R and Car-S mice maintain a large difference in sensitivity to skin tumour induction. Car-S mice are also more susceptible than Car-R mice to complete carcinogenesis produced by single or repeated applications of DMBA only. On the contrary, when DMBA or B[a]P are administered by subcutaneous injection rather than by topical application, no significant difference in tumour incidence is observed between the two lines. All tumours induced by topical administration of carcinogens on the skin are of epithelial origin, whereas the tumours produced by subcutaneous injection are of connectival origin. These observations suggest a tissue-specific effect of the selected genes, probably restricted at the skin level.

Journal Article.  0 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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