Journal Article

Mutagenic specificities and adduct distributions for 7-bromomethylbenz[<i>a</i>]anthracenes

John E. Page, Helen L. Ross, C.Anita H. Bigger and Anthony Dipple

in Carcinogenesis

Volume 17, issue 2, pages 283-288
Published in print February 1996 | ISSN: 0143-3334
Published online February 1996 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.2.283
Mutagenic specificities and adduct distributions for 7-bromomethylbenz[a]anthracenes

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Mutation induction in the supF gene of the plasmid pS189 by 7-bromomethylbenz[a]anthracene and 7-bromomethyl-12–7-bromomethylbenz[a]anthracene was examined. The former compound was substantially more mutagenic than the latter but a much greater proportion of the total mutations were located at mutation hotspots for the 12-methyl derivative. The overall correlation between sites of mutation and sites of polymerase arrest (anindicator of adduct formation) through the supF gene was poor. Although these bromo-compounds should formonly a single guanine adduct (unlike dihydrodiol epoxides that from both cis and transadducts) more than one mutational change was found at a given site, although the predominant base substitution was G→for either compound.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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