Journal Article

Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice

Kenzo Yamanaka, Kaori Ohtsubo, Akira Hasegawa, Hiroyuki Hayashi, Hiroshi Ohji, Masayoshi Kanisawa and Shoji Okada

in Carcinogenesis

Volume 17, issue 4, pages 767-770
Published in print April 1996 | ISSN: 0143-3334
Published online April 1996 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.4.767
Exposure to dimethylarsinic acid, a main metabolite of inorganic
                    arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide
                    in the lungs of mice

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The effect of dimethylarsenics on the pulmonary tumorigenesis initiated by 4-nitroquinoline 1-(4NQO) in mice was examined. The exposure of mice to dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics in mammals, resulted in not only promotion but also progression of the tumorigenic process in the lungs of mice administered 4NQO. Furthermore, dimethylarsenice influenced the differentiation process in lung tumorigenesis by 4NQO. These results may pave the way for the elucidation of lung carcinogenesis caused by arsenics.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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