Journal Article

SHORT COMMUNICATION: Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers

Mark Deakin, James Elder, Charles Hendrickkse, Daniel Peckham, David Leopard, Douglas A. Bell, Peter Jones, Hamish Duncan, Kate Brannigan, Julie Alldersea, Anthony A. Fryer and Richard C. Strange

in Carcinogenesis

Volume 17, issue 4, pages 881-884
Published in print April 1996 | ISSN: 0143-3334
Published online April 1996 | e-ISSN: 1460-2180 | DOI: https://dx.doi.org/10.1093/carcin/17.4.881
SHORT COMMUNICATION: Glutathione S-transferase GSTT1 genotypes and
                    susceptibility to cancer: studies of interactions with GSTM1 in lung, oral,
                    gastric and colorectal cancers

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Allelism in glutathione S-transferase GSTM1 and GSTT1 has been suggested as a risk factor in various cancers. Accordingly, we describe a group of case-control studies carried out to identify associations between GSTT1 genotypes and susceptibility to lung, oral, gastric and colorectal cancers. The frequencies of the putatively high risk GSTT1 null genotype were not increased in the lung, oral or gastric cancer cases compared with controls but the frequency of this genotype was significantly increased (P = 0.0011, odds ratio = 1.88) in the colorectal cancer cases. No significant interactions between the GSTT1 and GSTM1 null genotypes were identified in the cancer groups studied. Indeed, no significant associations between GSTM1 genotypes and susceptibility were identified though further evidence was obtained that the protective effect of GSTM1*A and GSTM1*B is not equal. The data complement studies showing that GSTT1 null is associated with an increased susceptibility to total ulcerative colitis and suggests that this enzyme is important in the detoxification of unidentified xenobiotics in the large intestine.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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