Journal Article

SHORT COMMUNICATION: TPA decreases the p53 response to benzo[<i>a</i>]pyrene-DNA adducts <i>in vivo</i> in mouse skin

Terhi Tapiainen, Kaisu Järvinen, Paavo Pääkkö, Nina Bjelogrlic and Kirsi Vähäkangas

in Carcinogenesis

Volume 17, issue 6, pages 1377-1380
Published in print June 1996 | ISSN: 0143-3334
Published online June 1996 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.6.1377
SHORT COMMUNICATION: TPA decreases the p53 response to
                        benzo[a]pyrene-DNA adducts in vivo in
                    mouse skin

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TPA, a well-known tumor promoter, decreased the response of nuclear P53 immunoreactivity to benzo[a]pyrene-7, 8-diol-9, 10-epoxide (BPDE)-DNA adducts in C57BL/6 mouse skin in vivo. A dose-dependent increase in both the level of BPDE-DNA adducts and nuclear p53 immunoreactivity was found in mice treated topically with 50–750 μg benzo[a]pyrene. Such a positive correlation between the adducts and p53 positivity was suggested by an earlier study. Since p53 probably functions in DNA damage control, interference by TPA with the p53 response could be a mechanism in TPA- induced tumor promotion. Whether such a mechanism is more general in tumor promotion deserves further study.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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