Journal Article

SHORT COMMUNICATION: Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor

Annette Clairmont, Dirk Tessmann, Anke Stock, Swantje Nicolai, Wilhelm Stahi and Helmut Sies

in Carcinogenesis

Volume 17, issue 6, pages 1389-1391
Published in print June 1996 | ISSN: 0143-3334
Published online June 1996 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.6.1389
SHORT COMMUNICATION: Induction of gap junctional intercellular
                    communication by vitamin D in human skin fibroblasts is dependent on the nuclear
                    vitamin D receptor

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The physiologically active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10−7. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication. Parallel to the increase in cell-cell communication, we observed a VDR-dependent increase in connexin 43 protein and connexin 43 mRNA levels. These results suggest that 1α, 25-dihydroxyvitamin D3 affects gap junctional intercellular communication at the level of transcription or of mRNA stability via the nuclear VDR.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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