Journal Article

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION: Transferrin C3 offers protection against smoking-associated lung cancer?

C. Sikström, L.E. Beckman, A. Eklund and L. Beckman

in Carcinogenesis

Volume 17, issue 7, pages 1447-1449
Published in print July 1996 | ISSN: 0143-3334
e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.7.1447
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION: Transferrin C3 offers protection against smoking-associated lung cancer?

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In previous investigations increased body iron stores and transferrin (TF) variants have been found to be associated with adverse health effects, including cancer. In this investigation transferrin C (TF C) subtypes were studied in lung cancer patients and controls from the Stockholm area in central Sweden. There was a significant difference between patients and controls with respect to the distribution of TF C alleles and genotypes, which was mainly due to a low frequency of the TF*C3 allele among the patients (P = 3×10−6). However, in adenocarcinoma the frequency of TF C3 types was almost identical to that among the controls, whereas in the smoking-related (squamous and small cell) tumor types the TF C3 frequency was remarkably low (OR = 0.03, 95% CI= 0.00–0.22). Thus individuals with the TF C3 variant appear to enjoy an almost complete protection against smoking-related lung cancer, The frequency of individuals carrying the protective TF C3 variant is -17% in central Sweden and 25% in Finland, which has the highest TF*C3 frequency found so far. The mechanism behind the observed association, which appears to be independent of iron binding and body iron stores, remains to be elucidated.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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