Journal Article

Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures

S.M. Clutton, K.M.S. Townsend, C. Walker, J.D. Ansell and E.G. Wright

in Carcinogenesis

Volume 17, issue 8, pages 1633-1639
Published in print August 1996 | ISSN: 0143-3334
e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.8.1633
Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures

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There is accumulating evidence that cells exposed to low and often environmentally relevant doses of ionizing radiation survive the initial insult, but transmit genomic instability to their progeny. The underlying mechanism of radiationinduced genomic instability is unknown. We present biochemical evidence consistent with the hypothesis that enhanced and persistent oxy-radical activity may be responsible.

Journal Article.  0 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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