Journal Article

Effects of chemopreventive selenium compounds on Jun N-kinase activities

Victor Adler, Matthew R. Pincus, Scott Posner, Pramod Upadhyaya, Karam El-Bayoumy and Ze'ev Ronai

in Carcinogenesis

Volume 17, issue 9, pages 1849-1854
Published in print September 1996 | ISSN: 0143-3334
Published online September 1996 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/17.9.1849
Effects of chemopreventive selenium compounds on Jun N-kinase
                    activities

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Activation of Jun-N-kinases (JNK) is stimulated by diverse agents including UV-irradiation, heat shock, tumor necrosis factor and osmotic shock. In the present study we have elucidated the effect of the organoselenium chemopreven-tive agent l, 4-phenylenebis(methylene)selenocyanate (p-XSC), on UV-mediated JNK activation. Using mouse fibroblasts as a model cell system we found that low concentrations (1–10 μM range) of p-XSC did not affect JNK activity, yet were capable of potentiating JNK activity when administered prior to UV-irradiation. While higher doses of p-XSC have minimal effect on JNK activation, when combined with UV, there is a dose-dependent decrease in JNK activation. Similar to its effects on JNK, p-XSC is a potent inducer of src-related tyrosine kinases.p-XSC mediated changes in JNK activation correlate with its ability to potentiate the association of JNK with p21ras, in a manner similar to that we have previously observed with GTP or sodium vanadate. That p-XSC can modulate JNK activities points to a possible mechanism by which it contributes to the cell's ability to cope with stress.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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