Journal Article

Hematologic malignancies developing in Syrian golden hamsters during induction of pancreatic carcinoma

Hernani D. Cualing, Stephen P. Povoski, Rawia S. Yassin, Cecilia M. Fenoglio-Preiser and Richard H. Bell

in Carcinogenesis

Volume 17, issue 9, pages 1983-1988
Published in print September 1996 | ISSN: 0143-3334
Published online September 1996 | e-ISSN: 1460-2180 | DOI:
Hematologic malignancies developing in Syrian golden hamsters during
                    induction of pancreatic carcinoma

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We report 30 hematologic malignancies arising in 25 of 236 Syrian golden hamsters (SGH) that received combinations of N-nitrobis(2-oxopropyl)amine (BOP) and Strepto-zotocin (STZ). Lesions developed with morphological similarity to human small lymphocytic (n= 7), diffuse mixed (n = 2), diffuse large cell lymphoma (n = 13), follicular lymphoma (n = 2), anaplastic large cell lymphoma (n = 3), hairy cell leukemia (n = 2), malignant histiocytosis (n = 1) and discordant lymphomas (n = 5). The types and distribution of these lesions are different from epizootic lymphomas in SGH. We also report a higher percentage (12 versus 4.6%) and the earlier appearance (≦40 versus 80–112 weeks) compared with aging-associated spontaneous SGH lymphoma. The features of these hematologic malignancies have not been previously reported in epizootic or aging-associated spontaneous lymphomas and therefore suggest a new class of hematologic lesions in SGH. Benign and atypical hyperplasia correlated with STZ administration (r = 0.97, P = 0.03). The malignant lesions correlated with areas of lymphoid hyperplasia (r = 0.78, P= 0.004). Only one of the 21 untreated SGH spontaneously developed a low grade lymphoma. The unusual types, distribution and occurrence of these lesions may suggest a role for these carcinogens in their induction.

Journal Article.  0 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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