Journal Article

Tamoxifen-induced DNA adducts in leucocytes of breast cancer patients.

K Hemminki, H Rajaniemi, M Koskinen and J Hansson

in Carcinogenesis

Volume 18, issue 1, pages 9-13
Published in print January 1997 | ISSN: 0143-3334
Published online January 1997 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/18.1.9
Tamoxifen-induced DNA adducts in leucocytes of breast cancer patients.

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Tamoxifen-induced DNA adducts were searched in leucocyte DNA from breast cancer patients. Total white blood cell DNA from tamoxifen-treated and control patients was analysed by 32P-postlabelling using HPLC-radioactivity detection. Rat liver DNA was used as a positive standard. In blinded analysis four of the six treated patients showed DNA adducts; none of the five controls were positive. The identity of fraction as a tamoxifen adduct was confirmed by using different chromatographic systems, each with spiked rat liver samples. The level of adducts in the treated patients was 5.5 adducts/10(9) nucleotides as compared to an apparent level of 1.9/10(9) in the controls.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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